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Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline

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Author(s): Satyanarayana Rentala | Sudhakar Konada | Ramakrishna Chintala | Lakshmi Narasu Mangamoori | Suryanarayana Murthy Upadhyayula | Sarva Mangala Dhurjeti

Journal: Bioinformation
ISSN 0973-2063

Volume: 9;
Issue: 14;
Start page: 721;
Date: 2013;
Original page

Keywords: Cataract formation | Oxidative stress | gamma-D-crystallin | Anti-oxidants | Docking scores.

ABSTRACT
Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.
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