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DOES A SINGLE BOLUS DOSE OF TRANEXAMIC ACID REDUCE BLOOD LOSS AND TRANSFUSION REQUIREMENTS DURING HIP FRACTURE SURGERY? A PROSPECTIVE RANDOMEZED DOUBLE BLIND STUDY IN 67 PATIENTS

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Author(s): M. Sadeghi A. Mehr-Aein

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 45;
Issue: 6;
Start page: 437;
Date: 2007;
Original page

Keywords: antifibrinolytics | blood loss

ABSTRACT
Extensive blood loss in total hip surgery is well known and is associated with a high transfusion rate of allogeneic blood. The aim of this study is to assess the effects of intraoperative tranexamic acid on post-operative bleeding and need for allogeneic transfusion during hip fracture surgery. We investigated 67 patients undergoing hip fracture surgery in a prospective, randomized, double-blinded study. 32 patients received tranexamic acid (TA) given in a bolus dose of 15 mg/kg before surgical incision. The remaining, 35 patients were allocated as control group. Postoperative bleeding, transfusions, complications, and hospital stay were recorded. The intraoperative bleeding was significantly lower in the TA group (652 ± 228 ml vs. 1108 ± 372 ml, p
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