Academic Journals Database
Disseminating quality controlled scientific knowledge

The Drosophila melanogaster host model

ADD TO MY LIST
 
Author(s): Christina O. Igboin | Ann L. Griffen | Eugene J. Leys

Journal: Journal of Oral Microbiology
ISSN 2000-2297

Volume: 4;
Start page: 1;
Date: 2012;
Original page

Keywords: Drosophila melanogaster | Porphyromonas gingivalis | Pathogen-host interactions | Periodontitis

ABSTRACT
The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen–host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial–host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis–host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed.

Tango Jona
Tangokurs Rapperswil-Jona

     Save time & money - Smart Internet Solutions