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DRUG NEOMYCIN RELEASE FROM CORDIA DICHOTOMA TRANSDERMAL FILM AND ANTIINFLAMMATORY ACTIVITY

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Author(s): A A Shahapurkar | Jayanthi

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 107;
Date: 2011;
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Keywords: Cordia dichotoma Transdermal Film | Neomycin | Anti-Inflammatory Activities.

ABSTRACT
Transdermal Films were prepared using 10 % w/v natural polymer (fruit gum) of Cordia dichotoma with different percentage of plasticizer (glycerin 0.10, 0.20 and 0.25 % w/v), same percentage of preservative (methyl paraben 0.1 % w/v) and drug (neomycin 0.2 % w/v). The films were casted on glass plates and dried under controlled evaporation. Films prepared with 0.20 % w/v of glycerin showed satisfactory drying after 24 h. They were evaluated by the various parameters like thickness, tensile strength, water uptake, folding endurance, piercing load and skin irritation test. In the present study Cordia dichotoma Transdermal film was investigated for Anti-Inflammatory activity in carrageenan-induced rat paw edema. It was compared to control group and with that of standard drug,diclofenac sodium. The neomycin film with 0.20% plasticizer showed significant result.
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