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E-Cadherin Expression as a Prognostic Factor in Transitional Cell Carcinoma of the Bladder After Transurethral Resection

Author(s): Mohammad Hatef Khorrami | Mazaher Hadi | Mohammad Reza Gharaati | Mohammad Hossein Izadpanahi | Amir Javid | Mahtab Zargham

Journal: Urology Journal
ISSN 1735-1308

Volume: 9;
Issue: 3;
Start page: 581;
Date: 2012;
Original page

Keywords: urinary bladder neoplasm | transitional cell carcinoma | cadherins | recurrence

PURPOSE: To analyze the role of negative versus positive immunoexpression of E-cadherin in recurrence rate of low-grade bladder tumors. MATERIALS AND METHODS: A total of 180 patients with unifocal, superficial, low-grade, papillary transitional cell carcinoma of the bladder were included in this study. The E-cadherin expression was evaluated using E-cadherin antibody. The patients were followed up for 36 months. Thereafter, recurrence rate of the tumor was compared between E-cadherin positive and negative groups. RESULTS: Of 180 low-grade carcinomas, E-cadherin immunoexpression was negative in 101 (56%) and positive in 79 (44%) patients. The recurrence rate in negative and positive groups was 65.6% and 37.9%, respectively. Negative in comparison with positive E-cadherin expression was associated with more disease recurrence (P = .045). CONCLUSION: There is an association between decreased E-Cadherin immunoexpression and tumor recurrence in low-grade and non-muscle invasive transitional cell carcinoma of the bladder.
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