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Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks

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Author(s): Li Yue | Yang Xiaojing | Ni Yingdong | Decuypere Eddy | Buyse Johan | Everaert Nadia | Grossmann Roland | Zhao Ruqian

Journal: Journal of Animal Science and Biotechnology
ISSN 1674-9782

Volume: 3;
Issue: 1;
Start page: 33;
Date: 2012;
Original page

Keywords: Feed restriction | Satellite cells | Proliferation | Gene expression | Chicken

ABSTRACT
Abstract Background Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0–14 day intermittent feeding led to persistent retardation in myofiber hypertrophy. However, how satellite cells respond to such nutritional insult has not been adequately elucidated. Results One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of intermittent feeding) groups. Chickens were killed on Day 15 and satellite cells were isolated. When cultured, satellite cells from the IF group demonstrated significant retardation in proliferation and differentiation potential, while RF partly restored the proliferation rate and differentiation potential of the satellite cells. Significant up-regulation of insulin like growth factor I receptor (IGF-IR) (P
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