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Early detection of prostate cancer from body fluids using DNA promoter methylation

Author(s): Raluca Dumache | Maria Puiu | Serban Negru | Radu Minciu | Bogdan Bumbacila

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 11;
Issue: 2-3;
Date: 2010;
Original page

Prostate cancer is the second most common cancer and the second leading cause of cancer death in men. Epigenetic alterations including hypermethylation of gene promoters are believed to be the early events in neoplastic progression and thus these methylated genes can serve as biomarkers for the early detection of cancer from clinical specimens, such as: tissue biopsies, serum and urine.Early detection of PCa from body fluids, can be done by molecular detection of some epigenetic biomarkers, such as: GSTP1, RASSF1A and RARβ2 gene promoters

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