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Early experience of outpatient parenteral antibiotic therapy for infected joint replacements.

Author(s): Sudhahar TA

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 2;
Issue: 5;
Date: 2005;
Original page

Keywords: out patient | antibiotic therapy

We have retrospectively analysed our first year’s experience with outpatient parenteral antimicrobial therapy (OPAT) for two-stage hip and knee revisions and compared this with previous in-patient antibiotic treatment using Hickman lines. Significant differences (p value < 0.01) are seen in length of stay, 14 days with OPAT versus 54 days with Hickmann line. Easy and safe self-administration is possible with OPAT using peripherally inserted central venous catheter (PICC) line. This represents an average cost saving per patient of £7000. No patient has had a significant complication from OPAT and at present there have been no re-infections. We conclude therefore that early mobilisation and OPAT can be safely considered for suitable patients under going a two-stage revision of an infected joint prosthesis as an alternative to prolonged hospital stay.
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