Academic Journals Database
Disseminating quality controlled scientific knowledge

Early onset cerebellar ataxia with retained tendon reflexes (EOCA) and olivopontocerebellar atrophy (OPCA) : a computed tomographic study.

Author(s): Pal P | Jayakumar P | Taly A | Nagaraja D | Rao S

Journal: Neurology India
ISSN 0028-3886

Volume: 47;
Issue: 4;
Start page: 276;
Date: 1999;
Original page

Keywords: Adolescent | Adult | Age of Onset | Aged | Cerebellar Ataxia | physiopathology | radiography | Child | Child | Preschool | Female | Human | Male | Middle Aged | Olivopontocerebellar Atrophies | physiopathology | radiography | Reflex | Stretch | physiology | Tomography | X-Ray Computed

Computed tomographic (CT) studies in olivopontocerebellar atrophies (OPCA) and ′early onset cerebellar ataxia with retained tendon reflexes (EOCA)′ are few and vary widely in methodology and criteria for cerebellar and brainstem atrophy. In this prospective study, CT scan observations on 26 patients (EOCA-11, OPCA-15) were compared with 31 controls using qualitative and quantitative assessment of cisterns, ventricles and atrophy of brain. Vermian and/or cerebellar hemispheric (predominantly anterior) atrophy was present in 80.8% and both were equally common. Cerebral cortical atrophy (26.9%) and leukoariosis (15.4%) were less frequently seen. Statistically significant atrophy of pons, brachium pontis, cerebellum and midbrain was noted in patient group. No significant differences were observed between EOCA and OPCA groups. Evidence of atrophy did not correlate with either the duration of illness or the severity of cerebellar ataxia in both the groups. The severity of brainstem atrophy in 14 patients with and 12 patients without abnormal brainstem auditory evoked response did not differ significantly. This study highlights the methodology of CT evaluation for brainstem and cerebellar atrophy, draws attention to cerebral atrophy and emphasizes the lack of significant differences in CT morphology between OPCA and EOCA patients.
Save time & money - Smart Internet Solutions     

Tango Rapperswil
Tango Rapperswil