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Early onset primary pulmonary cryptococcosis in a renal transplant patient

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Author(s): Tarai B | Kher V | Kotru P | Sabhikhi A | Barman P | Rattan A

Journal: Indian Journal of Medical Microbiology
ISSN 0255-0857

Volume: 28;
Issue: 3;
Start page: 250;
Date: 2010;
Original page

Keywords: Antifungal susceptibility | cryptococcal antigen | pulmonary cryptococcosis

ABSTRACT
We report a case of primary pulmonary cryptococcosis in a post-renal transplant patient. A 65-year-old male renal transplant patient was admitted to the hospital with a low grade fever of 1 month, radiologically mimicking tuberculosis (TB). Broncho-alveolar fluid (BAL) shows capsulated yeast, and Cryptococcus neoformans was grown on culture supported by cytology and histopathological examination. Cryptococcal antigen was positive (32-fold) in serum and was negative in cerebrospinal fluid (CSF). The patient was given amphotericin B and 5-flucytosine and clinical improvement was seen on a weekly follow up. The serum cryptococcal antigen test might contribute to the early detection and treatment of pulmonary cryptococcosis. The results of antifungal susceptibility were aid in selecting the drug of choice for treatment.
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