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Efecto de la quercetina sobre la nefrotoxicidad producida por cadmio

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Author(s): A. I. Morales Martín | C. Santiago Sandoval | F. Pérez Barriocanal | J Mª Fernández Tagarro | J.M. López Novoa | Vicente Sánchez

Journal: Revista de Toxicología
ISSN 0212-7113

Volume: 21;
Issue: 1;
Start page: 23;
Date: 2004;
Original page

Keywords: cadmium | quercetin | nephrotoxicity | oxidative stress | antioxidant

ABSTRACT
Effect of quercetin in cadmium-induced nephrotoxicity. Increased levels of cadmium in the environment have augmented the incidence of chronic cadmium-induced intoxication over the past few years. Oxidative stress is one of the mechanisms involved in cadmium-toxicity which manifests itself as renal injury, leading to renal dysfunction. Quercetin, one of the most abundant flavonoids present in the mediterranean diet, is a strong antioxidant and a good chelator of metals. Our aim was to study whether the administration of quercetin might offer protection against cadmium nephrotoxicity. Experiments were carried out in male Wistar rats weighing approximately 200 g. The study consisted of three experimental groups: 1) rats that received cadmium (1,2 mg/kg body weight, s.c.), 5 times/week, up to week 9; 2) rats that received quercetin (50 mg/kg body weight, i.p.), 5 times/week beginning from week 4; and 3) rats that received both cadmium and quercetin. Renal toxicity was evaluated by measuring proteins, microalbumin and glucose in urine, as well as urinary excretion of the following enzymes: Nacetyl- b-D-glucosaminidase, alkaline phosphatase and gammaglutamyl- transpeptidase. Plasma concentrations of creatinine and blood urea nitrogen were determined. Malondialdehyde concentration in plasma was used as an index of lipid peroxidation. Total antioxidants found in plasma were also measured. Kidney samples were used to analyze changes in the activity of the antioxidative enzymes, superoxide dismutase and glutathione- reductase. Our results show that the administration of cadmium over a nine-week period induced an increase in urinary flow, as well as in protein, microalbumin and glucose concentration in urine. Treatment with cadmium also increased serum creatinine and blood urea nitrogen, and drastically elevated the presence of enzyme activity in urine. Finally, as a result of functional renal damage, creatinine clearance was reduced. Animals that received both cadmium and quercetin showed a

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