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Efectos del Pycnogenol y Vitamina E, sobre la actividad de la Glutatión Peroxidasa y la formación de ateromas, en conejos expuestos a dieta hiperlipidémica

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Author(s): Leticia Figueira | Julio César González M | Molly Armas | Aldo Reigosa

Journal: Salus Online
ISSN 1316-7138

Volume: 14;
Issue: 3;
Start page: 33;
Date: 2010;
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Keywords: Pyc | Vit E | GPx | Atherosclerosis | Antioxidants

ABSTRACT
Antioxidants have been used to slow down or inhibit atherosclerosis. The objective of the present study was to compare the effect of Pycnogenol (Pyc), and Vitamin E (Vit E), separately and combined, on serum Glutathione peroxidase activity (GPx), and on the formation of aortic lesions in rabbits. 50 rabbits were studied: Group1: “conejarina” (commercial rabbit food) and vegetables; Group2: egg and conejarina, Group3: egg, conejarina and Pyc, Group4: egg, conejarina and Vit E, Group5: egg, conejarina, Pyc and Vit E. The doses were: Pyc (5mg/day), Vit E (200mg/day). The experiment lasted 12 weeks. Lipid profile was done by enzymatic methods, GPx by kinetic method and Vit E by HPLC, in weeks 0, 6 and 12. Histological study of rabbit’s aorta was done. GPx in groups 2, 3, 4 and 5 increased, compared with controls, from week 6 and 12 of experimentation (p
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