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Effect of 6-shogaol and 6-gingerol on Diclofenac Sodium Induced Liver Injury

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Author(s): Saleh Alqasoumi | Hasan Yusufoglu | Abdullah Farraj | Aftab Alam

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 7;
Issue: 8;
Start page: 868;
Date: 2011;
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Keywords: biochemical parameter | Shogaol | gingerol | diclofenac sodium | anti-hepatotoxicity | malondialdehyde

ABSTRACT
This study was designed to investigate the protective effect of 6-shogaol and 6-gingerol against hepatotoxicity induced by diclofenac sodium (DFS). Compounds 6-shogaol and 6-gingerol were isolated from 5% gingerol oleoresin and their potential hepatoprotective activity was evaluated. Hepatotoxicity was induced in rats by an intra-peritoneal (i.p.) injection of DFS (150 mg kg-1). Rats were i.p. injected with 6-shogaol and 6-gingerol (10 mg kg-1) for 6 days before induction of hepatotoxicity. Blood and liver sample were taken from each rat at 24 h post intoxication. Serum activity of liver marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed. Levels of alkaline phosphates enzymes (ALP) and total bilirubin in serum and malondialdehyde (MDA) in the liver homogenate were also estimated. Moreover, liver injury was assayed histologically. Results of present study revealed that i.p. injection of DFS to rats induced hepatic damaged that was manifested by significant (p
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