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The effect of acute decompansated hearth failure treatment on oxidative stress

Author(s): Turgay Ulaş | Hakan Büyükhatipoğlu | Yusuf Sezen | Mehmet Sinan Dal | Timuçin Aydoğan | Mehmet Ali Eren | Mehmet Uçar | Nurten Aksoy | Recep Demirbağ

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 3;
Start page: 267;
Date: 2011;
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Keywords: Heart failure | treatment | oxidative stress

Objectives: Myocardial dysfunction in patients with hearth failure is suggested to occur due to membrane changes caused by oxidative stress. The aim of this study is to evaluate whether there is a relationship between the degree of hearth failure and oxidative stress, and the effect of hearth failure therapy on oxidative stress parameters.Materials and methods: We measured enzyme activities of catalase (CAT) and lipid hydroperoxide (LOOH) from blood samples of 67 patients with decompensate hearth failure (pre-treatment group), who have compensated with the treatment (post-treatment group, n=54) according to clinical findings and two-dimensional echocardiography and 47 healthy volunteers (control group).Results: We found CAT enzyme activities of patients with pre- and post-treatment groups were significantly lower than in control subjects (15.76±2.28 U/L; 17.36±1.55 U/L; 20.50±2.52 U/L, respectively, p

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