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Effect of alpha-tocopherol on tissue transglutaminase and reversibility of thioacetamide-induced liver fibrosis in rats [Alfa-tokoferol'ün doku transglutaminazlar üzerine etkisi ve sıçanda tiyoasetamid uyarımlı geridönüşümlü karaciğer fibrozu]

Author(s): Mohamed S. El Borai | Waffa M. Ibrahim | Mohamed Hessien | Mai M. El-keey

Journal: Türk Biyokimya Dergisi
ISSN 0250-4685

Volume: 31;
Issue: 1;
Start page: 13;
Date: 2006;
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Keywords: Liver fibrosis | tissue transglutaminase | α-tocopherol | thioacetamide.

Both experimental and clinical studies have suggested the association between the deposition and stabilization of the extracellular matrix (ECM) proteins, and the development of liver fibrosis. Tissue transglutaminase (tTG) is known to stabilize the ECM proteins by its crosslinking activity that may play a key role in the development of liver fibrosis. This work was designated to evaluate the curative and/or the protective effect of α-tocopherol in relation to the activity of tTG in liver fibrosis. To establish this goal the effects of α-tocopherol on oxidative stress (measured as malondialdehyde, MDA), liver fibrosis (evaluated histologically and as hepatic collagen), and the activity of tTG were investigated in liver fibrosis generated in rats by intraperitoneal injection (i.p.i.) of thioacetamide (TAA). The data showed that α-tocopherol, significantly decreased the level of hepatic malondialdehyde when it was administrated after or before TAA treatment (P
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