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EFFECT OF ANISOCHILUS DYSOPHYLLOIDES BENTH. (LAMIACEAE) ON CARBONTETRA CHLORIDE (CCl4) INDUCED HEPATOTOXICITY IN RATS

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Author(s): Pandancode Chandran Sajitha | Karupannan Arumugasamy | Uthaman Danya | Thimmiyan Baluprakash | Madathupatti Ramanathan Udhayasankar

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 10;
Start page: 19;
Date: 2011;
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Keywords: Anisochilus dysophylloides | carbon tetrachloride | SGOT | SGPT | SALP | Silymarin.

ABSTRACT
The hepatoprotective effect of Anisochilus dysophylloides was evaluated on carbon tetrachloride (CCl4) induced in rats. The liver marker enzymes such as serum glutamate oxaloacetate (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosaphate (serum ALP) levels were significantly increased in Group II while the serum total protein, albumin and globulin levels were significantly decreased in Group II. The SGOT, SGPT, ALP and bilirubin levels were significantly decreased in Group III and IV at the dose of 100 and 200mg/kg b.wt. However, the serum total protein, albumin and globulin levels were elevated in the same Group II and IV. A. dysophylloides ethanolic extract also neutralized lipid peroxidation (LPO), glutathione peroxidase (GPX), glutathione reductase GRD, super oxide dismutase (SOD) and catalase (CAT) levels at a dose of 200mg/kg b.wt. Silymarin used as standard drug also exhibited significant hepatoprotective activity on post treatment against CCl4 hepatotoxicity in rats. The results of this study strongly indicate that A. dysophylloides has a potent hepatoprotective action against carbontetra chloride induced hepatic damage in rats.
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