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Effect of antihypertensive therapy on metabolic profile and erectile function in hypertensive men with high cardiovascular risk: focus on the combination of lisinopril and amlodipine

Author(s): M.N. Mamedov | M.V. Stroeva | M.N. Kovrigina | E.A. Poddubskaya

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 6;
Issue: 4;
Start page: 491;
Date: 2010;
Original page

Keywords: antihypertensive therapy | high cardiovascular risk | metabolic effects | erectile dysfunction.

Aim. To study the antihypertensive and metabolic effects of lisinopril plus amlodipine combination in hypertensive men with high cardiovascular risk.Materials and methods. Hypertensive men (n=21) with high cardiovascular risk (SCORE scale >5%) aged 30-59 y.o. were included in the study. Questionnaire survey, blood pressure (BP) and heart rate measuring, anthropometric studies, evaluation of the plasma lipid profile, uric acid level and glucose tolerance test were performed at baseline and at the end of the study. Erectile function was assessed by International index of erectile function (IIEF) score. After the cancellation of previous antihypertensive drugs patients were prescribed lisinopril 10 mg QD and amlodipine 5 mg QD. The duration of the study was 6 months.Results. In 4 weeks of the treatment systolic and diastolic BP decreased by 9.3 and 5.2%, and in 24 weeks – by 14.7 and 7.2% respectively (p

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