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Effect of Arsenic on the Disposition Kinetics of Sulphadimidine and Protective efficacy of Pipali (piper longum) in Cockerels

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Author(s): Ram Sajan | S.P. Singh | Rachna Varma | G. K. Choudhary | Atul Prakash

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 7;
Issue: 2;
Start page: 175;
Date: 2008;
Original page

Keywords: Pharmacokinetics | Sulphadimidine | Arsenic | Cockerels | Piper longum | Intravenous (i.v.)

ABSTRACT
This study was designed to evaluate pharmacokinetics of sulphadimidine in cockerels fed on subclinical dose of arsenic (100 ppm) in diet and to determine the protective efficacy following simultaneous dietary medication with Piper longum (pipli) (100 ppm) in a 12-week feeding trial. Pharmacokinetic parameters were determined after single i.v. dose (50 mg/kg) of sulphadimidine in cockerels in three groups fed on 0 ppm arsenic(control), 100 ppm arsenic and arsenic plus powdered dried fruits of Piper longum (100 ppm each)), respectively, in ration for 12 weeks. The elimination half-life (t1/2 b, h), AUC (µg mL-1h) and MRT (h) were significantly (p

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