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Effect of beta-blockers on blood pressure, perioperative complications and hospital stay duration in patients with intermediate risk of cardiovascular complications after routine cholecystectomy: an open comparative randomized study

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Author(s): O.L. Barbarash | R.V. Repnikova | T.V. Shoforus | O.I. Golofaeva

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 6;
Issue: 5;
Start page: 667;
Date: 2010;
Original page

Keywords: cardiovascular complications | noncardiac surgery | beta-blockers | bisoprolol.

ABSTRACT
Background. More than 100 million adults are exposed to noncardiac surgical interventions every year worldwide, and cardiovascular complications happen in 500 000 - 900 000 patients.Aim. To evaluate the efficacy and safety of beta-blocker bisoprolol in the perioperative period in hypertensive patients during routine laparoscopic cholecystectomy.Material and Methods. Hypertensive patients (n=123) scheduled for laparoscopic cholecystectomy were examined. Patients were randomized into 2 groups. Patients of group 1 (n=57) received preoperatively bisoprolol, and patients of group 2 (n=66) had a correction of previously received antihypertensive therapy without beta-blockers addition. Patient examination included traditional preoperative tests as well as ambulatory blood pressure monitoring and echocardiography.Results. Heart rate was significantly lower in group 1 at admission (66.1±6.9 min-1) and before surgery (61.3±6.1 min-1) than in group 2 (74,5±8,2 and 73,9±7,0 min-1, respectively, p
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