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Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

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Author(s): Ruimin Chen | Gail J. Mick | Rongxian Xu | Daoxin Zheng | Yanfeng Fan | Xiangquan Lin | Kenneth L. McCormick

Journal: International Journal of Pediatric Endocrinology
ISSN 1687-9848

Volume: 2009;
Date: 2009;
Original page

ABSTRACT
The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23–36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P
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