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EFFECT OF CHAMOMILE OIL AS A PERCUTANEOUS ABSORPTION ENHANCER

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Author(s): Ali Heyam Saad | Shehab Naglaa Ahmed | El-ahaj Babiker Mohamed

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 9;
Start page: 66;
Date: 2013;
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Keywords: high-performance liquid chromatography | percutaneous absorption enhancer | Chamomile oil | Dimethyl Sulfoxide | Silver Sulfadiazine.

ABSTRACT
The aim of this study was to investigate the ability of Chamomile oil as absorption enhancers for cutaneously administered Silver Sulfadiazine by comparing it with a penetration enhancer Dimethyl Sulfoxide. Silver sulfadiazine is used in burn infection. Gel was selected as the vehicle for Silver Rat’ skin samples were placed in a continuous flow diffusion cell, with Silver Sulfadiazine gel on top. Receptor fluid samples were analyzed using high-performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analyzed. Addition of chamomile oil or Dimethyl Sulfoxide to the gel increased the percutaneous absorption of the drug. 5 % Chamomile oil was found to be the most efficient absorption enhancer in this comparison.
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