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Effect of Chronic administration of Landolphia owariensis extract on the activities of rat enzymes

Author(s): Ilesanmi, F. F, | Balogun, B. E | Ilesanmi, O. S, | Odusola, K. B | Onunkwor, O. B

Journal: Research Opinions in Animal & Veterinary Sciences
ISSN 2221-1896

Volume: 1;
Issue: 5;
Start page: 266;
Date: 2011;
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Keywords: Landolphia owarrensis | Kidney | Liver | Serum | Acid Phosphatase | Alkaline Phosphatase

Medicinal plants are generally taken without any dose measurement especially by the uneducated people, some of this extracts may pose a great health risk. The objective of this work was to assess the effect of chronic administration of Landolphia owariensis extract on the activities of acid phosphatase and alkaline phosphatase in the kidney, liver and serum of rats. The methanol extract was administered orally to albino rats on daily doses of 250 mg/kg and the activities of enzymes were monitored for 12 days. A total of 24 albino rats were divided into two groups. Landolphia owariensis was administered to 12 rats and saline solution was administered to the remaining 12 as control. The results showed non significant increase in alkaline and acid phosphatase activities in both liver and kidney. Also an increase in serum enzyme activity was observed, however, this was not statistically significant. No adverse effects were observed on kidney and liver despite the chronic administration
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