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Effect of Chronic Oral Administration of Chloroquine on the Weight of the Heart in Wistar Rats

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Author(s): Al-Hassan Mojimah Izunya

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 2;
Issue: 3;
Start page: 127;
Date: 2010;
Original page

Keywords: Antimalarial | cardiomyopathy | cardiotoxicity | chloroquine | heart

ABSTRACT
The effect of chronic oral administration of chloroquine, an antimalarial and antirheumatic drugon the weight of the heart in wistar rats w as investigated. Ten wistar rats were randomly grouped into two,control and treated. The treated group rats were administered 20 mg/kg body wt, weekly of chloroquine for4 weeks while the control group rats were given distilled water for 4 w eeks. The rats were fed with grower'smash purchased from Edo feeds and Flour Mill Ltd, Ewu, Edo state, Nigeria and were given w ater ad libitum.On day 29th of the experiment, the rats were weighed and sacrificed. The heart were carefully dissected out,freed from adherent tissues and weighed to the nearest 0.001 g. The result showed that chronic oraladministration of chloroquine resulted in significant increase in the weight of the heart (p

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