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The effect of combined antihypertensive therapy on the basic parameters of the left ventricle myocardium structure and function in women with metabolic syndrome and hypothyroidism

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Author(s): V.V. Skibitskiy | A.V. Fendrikova | N.E. Pykhalova

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 8;
Issue: 4;
Start page: 509;
Date: 2012;
Original page

Keywords: metabolic syndrome | hypothyroidism | myocardial remodeling.

ABSTRACT
Aim.To study the effect of combined antihypertensive therapy on the basic parameters of the left ventricle (LV) myocardium structure and function in women with arterial hypertension (HT), metabolic syndrome (MS) and hypothyroidism.Material and methods.Women (n=196) with HT grade 2–3 and MS were included into the study. Standard clinical examination including an assessment of thyroid status, ambulatory blood pressure (BP) monitoring and echocardiography was performed at baseline and after 6 months. The patients were split into 3 groups: control (without hypothyroidism) with subclinical and manifested (symptomatic) hypothyroidism (SH and MH). Depending on baseline heart rate (HR) patients of each group received a combination of amlodipine+losartan (A+L) in HR
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