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The Effect of Conjugated Linoleic Acids, Vitamin E and Their Com¬bination on Lipid Peroxidation in Active Rheumatoid Arthritis

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Author(s): N Aryaeian | M Djalali | F Shahram | A Djazayeri | MR Eshragian | N Nadery | F Fatehi | M Zarei | M Chamari

Journal: Iranian Journal of Public Health
ISSN 2251-6085

Volume: 38;
Issue: 2;
Start page: 79;
Date: 2009;
Original page

Keywords: Conjugated linoleic acid | Vitamin E | Lipid peroxidation | Active rheumatoid arthritis

ABSTRACT
"nBackground: Reactive oxygen species (ROS) have important role in the etiology and pathogenesis of Rheumatoid Arthritis (RA). We investigated the effect of conjugated linoleic acids (CLAs) and vitamin E on lipid peroxidation."nMethods: In a randomized, double-blind placebo, controlled, clinical trial 87 patients with active RA were enrolled. They were divided into 4 groups, received one of the following daily supplement for 3 months; 1- group C: 2.5gr CLA, that con­tained 2 gr 50:50 mix of cis 9-trans11 and trans 10-cis 12 CLAs, 2- group E: 400mg Vitamin E, 3- group CE: CLAs  plus vita­min E, 4- group P: placebo. After supplementation Glutathione peroxidase (GSH-Px) level increased in C, E and CE groups, CE group had  lower GSH-Px than P group(P≤ 0.05)."nResults: Glutathione reductase (GR) increased in CE, C and P groups. Catalase increased in all groups, but enhancement was significant in C and CE. Superoxide dismutase (SOD) decreased in E and C (P≤ 0.05). Catalase and SOD did not show signifi­cant differences between groups. Malondialdehyde (MDA) decreased significantly in all groups but this decrease was only significant in CE in comparison with other groups."nConclusion:  CLAs might be useful in reducing oxidative stress in RA
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