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Effect of cultural manipulations on antioxidant potential of tissue cultured Mentha spicata (SPR 8)

Author(s): Akashdeep, Pooja Rana, and Giridhar Soni

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3368;
Date: 2011;
Original page

Keywords: Antioxidant | Oxidative stress | Ferullic acid | Mentha spicata (SPR 8)

Oxidative stress appears in tissues and cells when there exists an imbalance between the pro-oxidants and antioxidants resulting in increased output of reactiveoxygen species. The body’s endogenous defenses may not be adequate to prevent the damages completely.Therefore, there is need to focus attention onexogenous sources of natural antioxidants that can be incorporated in the diet to modulate body’s antioxidant defense mechanisms.Some herbs/ mentha speciescan be important sources of natural antioxidant. The antioxidant properties of these vary with species and even cultural conditions. Keeping this in viewpresent study had been carried out to improve antioxygenic potential of the Mentha spicata (SPR 8) through cultural manipulations. Various in vitro modelsviz. hydroxyl, nitric oxide,super oxide radical scavenging potential, iron reducing power, iron chelation and inhibition of linoleic acid peroxidation revealedthat Mentha spicata (SPR 8) had good antioxygenic potential. Antioxygenic potential of these species were correlated to their phenolic contents. Theantioxygenic potential of Mentha spicata could be augmented through cultural manipulations by supplementing cultural medium with Tyrosine, Phenylalanineand Ferullic acid. These substrates like Tyrosine, Phenylalanine and Ferulic acid when added to tissue culture medium further improved antioxidant potentialas well as phenolic and flavonoid content of SPR-8. Of the substrates used ferulic acid was found to be more effective in comparison to Tyrosine and Phenylalanine.
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