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The Effect of Diabetic Nephropathy on the Lipid Profile of Diabetics in Southern Nigeria

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Author(s): Onovughakpo-Sakpa O. Ejuoghanran | Onyeneke E. Chukwu | Sakpa L. Christopher

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 11;
Issue: 4;
Start page: 198;
Date: 2011;
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Keywords: albumin creatinine ratio | Diabetic nephropathy | lipid profile | body mass index

ABSTRACT
Diabetic Nephropathy (DN) is a common cause of abnormal lipoprotein metabolism and can be influenced by impairment of renal function and metabolic control in diabetes. The aim of this study was to explore the lipid abnormalities in diabetic patients with nephropathy in comparison with diabetic patients without nephropathy. This was achieved by assaying plasma lipid fractions in diabetic patients and control. A total of 95 diabetic patients and 19 non-diabetic control subjects were used for the study. The patients were divided into 2 groups-those with diabetic nephropathy and those without diabetic nephropathy, using ACR = 30 mg g-1. Urinary albumin and creatinine were assayed by the Lowry method and the modified Jaffe method, respectively. Triglyceride was assayed by the glycerol-3-phosphate dehydrogenase method while total cholesterol and High Density Lipoprotein (HDL) cholesterol were assayed using the enzymatic end point method. Low Density Lipoprotein (LDL) cholesterol was determined by the Friedewald equation. Body Mass Index (BMI, kg m-2) was calculated from height and weight which were obtained from a questionnaire used to record the demographic features of all the volunteers/subject. Results obtained showed that plasma total cholesterol was significantly increased in diabetic volunteers without nephropathy (197.298.20, p
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