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Effect of Dietary Tocotrienols on Antioxidant Status and Low Density Lipoprotein Oxidation in Rats, Exposed to Cigarette Smoke

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Author(s): Amir Khan | Fouzia Ishaq | Abhay S. Chandel | Samir Chettri

Journal: Asian Journal of Clinical Nutrition
ISSN 1992-1470

Volume: 4;
Issue: 1;
Start page: 27;
Date: 2012;
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Keywords: LDL oxidation | atherosclerosis | hyperlipidemia | dyslipidemia | tocotrienols

ABSTRACT
Cigarette smoking is the one of the major causes of mortality and morbidity involving respiratory and cardiovascular illness in developing and developed countries. Smoking has been strongly implicated as a risk factor for chronic obstructive pulmonary disease, cancer and atherosclerosis. In this study we deal with the multiple therapeutic benefits of Tocotrienols dissolved in palm oil. Various parameters, such as blood carbonmonoxide saturation, blood nicotine and various lipid profiles, total antioxidant power, conjugated diene formation, malondialdehyde content and ex vivo and Cu++ mediated in vitro LDL oxidation, in addition to body weight were taken to consideration and were analyzed after 4 week administration of tocotrienols (6 mg mL-1) to smoke exposed rats useful in the prevention and treatment of tobacco-induced dyslipidemia/hyperlipidemia and atherosclerosis. As a conclusion, daily use of dietary tocotrienols will be efficacious, cost effective and a good source of vitamin-E.
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