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Effect of Ethanolic Extract of Hemidesmus indicus Roots on Cisplatin Induced Nephrotoxicity in Rats.

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Author(s): Arvinder Kaur,ac* Satyajit Singhb Annie Shirwaikarc, M. Manjunath Setty, c

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 8;
Start page: 2523;
Date: 2011;
Original page

Keywords: Hemidesmus indicus | Nephrotoxicity | Nephroprotection | Cisplatin

ABSTRACT
The ethanolic extract of the roots of Hemidesmus indicus was investigated for its nephroprotective activity in Cisplatin induced renal injury in rats. In the curative regimen, the ethanolic extract at dose levels of 250 and 500 mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine. There wasincrease in the GSH and GST enzyme level after treating rats with ethanolic extract of Hemidesmus indicus. The ethanolic extract also showed inhibition of Cisplatin induced lipid peroxidation. The results suggest that the alcoholic extract of the roots of Hemidesmus indicus possesses significant nephroprotective activity.
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