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Effect of Ethanolic Extract of Pisonia alba Span. Leaves on Blood Glucose levels and Histological Changes in Tissues of Alloxan-Induced Diabetic rats

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Author(s): C Sunil | P G Latha | S R Suja | V J Shine | S Shyamal | G I Anuja | S Sini | S Rajasekharan | P Agastian | S Ignacimuthu | V Kalichelvan

Journal: International Journal of Applied Research in Natural Products
ISSN 1940-6223

Volume: 2;
Issue: 2;
Start page: 4;
Date: 2009;
Original page

Keywords: Pisonia alba | Alloxan | antihyperglycemic | oxidative stress | in vitro antioxidant effects | histopathology

ABSTRACT
Summary: The ethanolic extract of Pisonia alba Span (Nyctaginaceae) (PAEt) was found to have antidiabetic activity that reduces blood sugar level in alloxan induced diabetic rats.  In this study, a 15 days antihyperglycemic effect of the two different doses (250 and 500 mg/kg b.w.p.o) of PAEt was investigated. Glibenclamide was used as a reference drug at a dose of 0.6 mg/kg b.w. Treatment of alloxan diabetic wistar rats with the extract caused a significant (P
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