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The Effect of Exam Stress on Serum IL-6, Cortisol, CRP and IgE Levels

Author(s): SA Shamsdin | M Anvar | D Mehrabani

Journal: Iranian Red Crescent Medical Journal
ISSN 1561-4395

Volume: 12;
Issue: 4;
Start page: 484;
Date: 2010;
Original page

Keywords: Stress | Immune system | IL-6 | IgE | CRP | Cortisol

Background: Stress has determining effects on the immune response. This study was undertaken to determinethe effect of exam stress on serum IL-6, cortisol, CRP and IgE levels of medical students.Methods: Thirty five university medical students in Southern Iran were enrolled. Two blood samples were providedfrom each participant one month (first stage) and one hour (second stage) before the exam at 1.00 PM.The students completed the SpielBerger State-Trait Anxiety Inventory (STAI) questionnaire. IL-6, cortisol, CRPand IgE changes were determined in these students.Results: The mean age of the students was 21 years. The exam stress resulted in a significant decrease in theIgE level and a significant increase in the cortisol level.Conclusion: The exam stress can result in a decrease in the IgE level and a significant increase in the cortisollevel. So, these changes may indicate the alterations of immunological status and presence of stress in an immunosuppressedindividual, affecting his/her health.
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