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The Effect of Exogenous Testosterone Administration on Peripheral Nerves Regeneration after Sciatic Nerve Compression in Rat

Author(s): M. Tehranipour | M. Kabiri

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 7;
Start page: 692;
Date: 2009;
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Keywords: Neuronal degeneration | testosterone | numerical density

There are extensive evidences those axonal processes of the nervous system (peripheral and/or central) may degenerate after nerve injuries. Wallerian degeneration and choromatolysis are the most conspicuous phenomena that occur in response to injuries. In this study the effects of exogenous testosterone administration on peripheral neurons regeneration after sciatic nerve compression in rat was investigated. Thirty-two male Wistar rats divided to 4 group (control, compression, compression+castrated, compression+subcutaneous administration testosterone n = 8). After 4 weeks the lumber segments of spinal cord were sample, processed, sectioned serially and stained with toluidine blue (pH = 4.65). By using sterological quantitative technique (physical dissector), the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared with each other. Statistical analysis showed that the number of motor neurons in compression group reduced significantly. In castration animal compression induced remarkable reduction in compare with control group. Treatment of testosterone (100 mg kg-1) at 4 week significantly (p
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