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EFFECT OF FEEDING OF HONEY MIXED WITH GHEE AND ITS HEATED FORMS ON HEPATOTOXICITY, ANTIOXIDANT ENZYMES AND LIPID PROFILE OF RATS

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Author(s): K R Anilakumar | A Annapoorani | Farahath khanum | NA Murthy | AS Bawa

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 6;
Start page: 1758;
Date: 2011;
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Keywords: Hepatotoxicity | Antioxidant | Lipid profile | glutathione transferase | alkaline phosphatase | phosphate dehydrogenase | conjugated dienes | hydroperoxides.

ABSTRACT
Honey and ghee are widely used in our diet. Ayurveda emphasized that heated honey and honey mixed with equal amount of ghee produce deleterious effects that eventually lead to death. This study reveals their effect on multicomponent antioxidant system in rat liver. Six groups of rats were maintained for 6 weeks as Control; Honey incorporated diet; Heated honey incorporated diet; Ghee incorporated diet; Honey with ghee incorporated diet and heated honey with heated ghee incorporated diet. Results revealed a significant raise in serum alkaline phosphatase, uric acid, hepatic glutathione S- transferase, glucose-6-phosphate dehydrogenase and γ-glutamyl transpeptidase with associated increase in serum conjugated dienes, hydroperoxides and malondialdehyde of rats fed with honey mixed ghee and heated honey mixed with heated ghee. Hence, it is concluded that consumption of honey with equal amount of ghee and its mixture in the heated forms raises the detoxifying enzymes and the levels of lipid peroxides in rat liver.
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