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The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats

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Author(s): Jamshid Narenjkar | Mehrdad Roghani | Hanieh Alambeygi | Farnoosh Sedaghati

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 2;
Issue: 3;
Start page: 51;
Date: 2011;
Original page

Keywords: Quercetin | Diabetes Mellitus | Antinociception | Formalin Test | Hot Tail Immersion Test | Oxidative Stressof

ABSTRACT
Introduction: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods: Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests. Meanwhile, some markers of oxidative stress were also measured in brain tissue.Results: Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p
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