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Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial

Author(s): Shahriar Shahriari | Aliasghar Rezaei | Seyed Mohsen Jalalzadeh | Khosro Mani | Alireza Zamani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 3;
Start page: 176;
Date: 2011;
Original page

Background: Bone resorption is one of the main features of inflammatory periapicallesions and is mainly mediated by interleukin-1 beta (IL-1β), tumor necrosis factoralpha(TNF-α) and prostaglandin-E2 (PGE2). Recent investigations of these lesionsrevealed that pharmacological modulation may be possible. Objective: The aim of thisstudy was to evaluate the effect of Ibuprofen on IL-1β, TNF-α and PGE2 levels inperiapical exudates and compare the results with a group of placebo control. Methods:Thirty patients with non vital teeth and radiographic lesions were divided into twogroups of case and control according to their entrance to the study. Periapical exudateswere taken from root canals using absorbent paper points and followed by 400 mgIbuprofen and placebo prescribed one tablet every 6 hour for three days and in thefourth day second samples were taken, then final cleaning, shaping and obturation of thecanals were completed. IL-1β, TNF-α and PGE2 levels were determined by enzymelinkedimmunosorbent assays (ELISA). Data were analyzed using paired t-test andstudent's t-test. Results: The results showed that PGE2 levels were decreasedsignificantly in the case group to 86.92 ± 72.42 Pg/ml following Ibuprofen treatmentcomparing with the pre-treatment (164.96 ± 12.255 Pg/ml) (p=0.02) and placebo group(154.2 ± 97.13 Pg/ml) (p=0.001). But there were no significant differences in IL-1β andTNF-α level between the two groups and in each group before and after treatment.Conclusion: The data indicate that Ibuprofen, as a non-steroidal anti-inflammatory drug(NSAID), can be used to block PGE2 release, enhance healing of inflammatoryperiapical lesions and possibly to inhibit bone resorption.

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