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Effect of intracerebroventricular injection of olive leaf extract on PTZ-induced seizures in male rats

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Author(s): Morteza Zendehdel | Keyvan Keramati | Sedigheh Garavand

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 15;
Issue: 1;
Start page: 108;
Date: 2011;
Original page

Keywords: Key words: Epilepsy | Olive-leaf extract | PTZ

ABSTRACT
Introduction: Olive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ. Methods: In this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg and 500 μg), before the intraperitoneal administration of PTZ (80 mg/kg) for induction of seizure. Then, seizure score and onset times of every stage of seizure were recorded during 20 minutes after PTZ administration. The data was analyzed by one-way analysis of variance (ANOVA) and non parametric tests. Results: Result of this research showed that the injection of 125, 250 and 500 μg of olive leaf extract had no effect on the onset time of seizure stages 1, 2 and 3 compared to the control group (P>0.05). However, they significantly decreased the onset time of seizure stages 4 and 5 compared to the control group (P
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