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The effect of intravenous iron therapy on total antioxidant capacity in patients with iron deficiency anemia

Author(s): Didem Gökçen Gürbüz | Turgay Ulaş | Fatma Paksoy | Özlem Kınık Akgün | İrfan Tursun | Adile Çakır | Mehmet Sinan Dal | Fatih Borlu

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 3;
Start page: 287;
Date: 2011;
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Keywords: Anemia | iron-deficiency | intravenous | therapy | oxidative stress

Objectives: Parenteral iron is used for patients who are either unable to absorb oral iron or who have increasing anemia despite adequate doses of per oral iron. Parenteral iron preparations are clearly effective, but concerns have been raised regarding adverse events and potentially long-term toxicity. So, in this study we aimed to investigate the effect of intravenous iron therapy on acute antioxidant capacity.Materials and methods: Totally 36 patients with iron deficiency anemia and 20 healthy controls were included in the study. Prior to iron infusion to subjects, blood samples were obtained for measurement of total antioxidant capacity. Then patients received 100 mg intravenous iron sucrose in an hour. And at the first hour after the infusion was completed, the blood samples were repeated.Results: Before the treatment total antioxidant capacity was significantly lower in anemic patients (280±34 μmol/L) than in control group (365±58 μmol/L) (p=0.001). Significantly decreased total antioxidant capacity (264±35 μmol/L) was found after the iron treatment (p=0.01). No adverse events related to intravenous iron were observed.Conclusion: In this study, we observed that intravenously administered iron sucrose in 100 mg dose and also iron deficiency anemia itself, caused increased oxidative stress. J Clin Exp Invest 2011; 2 (3): 287-291.
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