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Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats

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Author(s): Gabriel A. Agbor | Ibrahim Taga | Danielle R. Nguindex | Mohsin A. Zaidi | L.G. Lehman | Illimar Altosaar | Jeanne Y. Ngogang

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 7;
Issue: 6;
Start page: 726;
Date: 2011;
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Keywords: superoxide dismutase | catalase | Oxidative stress | carbonyl | thiol | TBARs

ABSTRACT
Oxidative stress is implied in numerous pathologies, including obesity, type 2 diabetes, atherosclerosis, inflammatory disorders and ageing. Antioxidants are known to neutralise the effects of oxidative stress. Hence, the present study was designed to evaluate the effect of iodine supplementation on the antioxidant status of alloxan monohydrate intoxicated rats. Two groups (A and C) of Wistar rats were kept normal (were not induced oxidative stress), while other two groups (B and D) were induced oxidative stress by alloxan monohydrate (150 mg kg-1) intoxication. Group A and B animals were fed normal rodent diet while group C and D animals diet was supplemented with iodine (KI, 25 mg kg-1 diet). The feeding lasted 6 weeks and the animals were sacrificed and the plasma and red blood cells hemolysate prepared from whole blood samples were used for biochemical analysis. Alloxan monohydrate intoxication induced a collapse in the antioxidant system characterized by a significant drop (p

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