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The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study

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Author(s): Martín Andrea | Urrets-Zavalia Julio | Berra Alejandro | Mariani Ana | Gallino Norberto | Demel Eduardo | Gagliardi Julio | Baena-Cagnani Carlos | Urrets-Zavalia Enrique | M Serra Horacio

Journal: BMC Ophthalmology
ISSN 1471-2415

Volume: 3;
Issue: 1;
Start page: 2;
Date: 2003;
Original page

ABSTRACT
Abstract Background The efficacy and safety of ketotifen eye drop treatment in allergic conjunctivitis (AC) management is perfectly known by several studies, but the mechanism of action at the biochemical levels is poorly understood so we decided to perform an open, uncontrolled study in order to investigate the effect of the topical administration of ketotifen fumarate 0.05% on biochemical markers of inflammation on conjunctival cells in patients with AC. Methods Nineteen patients with symptoms and signs of AC (itching, discharge, burning, redness, increase in the watery discharge, swelling and follicles) and with a history of allergy were prescribed with two daily instillation of one drop of eyewash ketotifen fumarate 0,05% in both eyes during thirty days. They were studied by measuring clinical and immunologic parameters. Results Ketotifen fumarate treatment significantly reduced the total symptoms and signs score for each patient as well as each symptoms and signs at all time points compared with day 0 (p < 0.0001 and p < 0.016, respectively). Although the percentage of HLA-DR+ epithelial cells diminished only in 58% of patients, the numbers of CD29+ and eotaxin+ epithelial cells dropped significantly in 68% and 73 % of them (p < 0.0062 and
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