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THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

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Author(s): A Arzi | AA Hemmati | S Ghobishavi | L Arzi

Journal: Jundishapur Journal of Natural Pharmaceutical Products
ISSN 1735-7780

Volume: 2;
Issue: 1;
Start page: 18;
Date: 2007;
Original page

Keywords: L-tyrosine | Vitamin E | Vitamin C | Perphenazine | Catatonia | Rat.

ABSTRACT
Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.
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