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EFFECT OF LEPTADENIA RETICULATA LINN ON STRESS MODULATED SEXUAL BEHAVIOR OF MALE RATS

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Author(s): Santosh B. T | Chitme H. R | Rabbani G | Jafar M

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 10;
Start page: 27;
Date: 2011;
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Keywords: Male infertility | Immobilization stress | Aphrodisiac | Sildenafil citrate | Testosterone | Spermatogenesis.

ABSTRACT
In the day today life the persons living and working in the area were the environmental factors such as chemical, physical, or emotional, stress may adversely affect the testicular functions that is enhancement of testicular germ cell apoptosis will takes place. All the organisms survive by maintaining a dynamic equilibrium with their environment. The organization of this homeostasis exists at molecular, cellular, physiological and behavioral levels. But some of the physical, mental, or emotional stress acts as a threat to this equilibrium, So this alteration in the homeostasis by stress will cause decreased libido, changes in the motor activity, increased arousal, vigilance and increased tolerance of pain.So the aim of the present study was to determine whether the Leptadenia reticulata plant methanolic and chloroform extracts in the low 50mg/kg, mid 100mg/kg, high 250mg/kg and a safety 200mg/kg oral dose will overcome the stress induced sexual dysfunction or not. So to evaluate whether the Leptadenia reticulata active constituents have got aphrodisiac as well as infertility treatment activity was assessed by studying the following sexual behavioral parameters, number of mounts, ejaculation latency, intromission interval, number of ejaculations and the histopathological study of testis, will give a clear idea of the study.In this study the obtained results will show that chloroform extract is having more potent aphrodisiac activity when compared to normal, because it has got increased number of mounts, intromission interval, Number of ejaculations and decreased latency of first mount as well as the increase in post ejaculation time shows its potent aphrodisiac in both normal and stressed rats. Significant (P
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