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Effect of Losartan and Ramipril on Oxidative stress and Anti-oxidant Status in South Indian Hypertensive Patients

Author(s): V. Uday Kiran | N. Venkat Rajaiah | D. Rama Krishna | Y. Narsimha Reddy

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 6;
Issue: 6;
Start page: 916;
Date: 2010;
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Keywords: oxidative stress | total anti-oxidant status | glutathione | Hypertension | malondialdehide | ramipril | losartan

Over production of oxygen free radicals, which is mainly mediated by super oxide, occurs in human hypertension. Ramipril and losartan are the drugs which found to be more prescribed drugs for hypertension patients. In the present study, an attempt has been made to evaluate the levels of serum Glutathione, Total anti-oxidant status, lipid peroxidation (malondialdehide) and liver function parameters like serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. Total 75 subjects were selected for study. Out of 75 subjects 25 were normal healthy volunteers and 50 subjects were patients who are untreated with hypertension. The patients both male and female within the age group of 25-65 years were selected. Glutathione, total anti oxidant status, lipid peroxidation, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase levels in plasma were estimated by using reported methods. Individual methods were standardized first and standard graphs were plotted and the parameters were measured significantly decreased values of glutathione, total anti oxidant status and malondialdehide were observed (p
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