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Effect of Mallotus Philippensis Muell.-Arg leaves against hepatotoxicity of Carbon tetrachloride in rats

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Author(s): Ramakrishna.S, | Geetha K.M, | Bhaskar gopal P.V.V.S, | Ranjit kumar P | Charan Madav. P, | Umachandar. L

Journal: International Journal of Pharma Sciences and Research
ISSN 0975-9492

Volume: 2;
Issue: 2;
Start page: 74;
Date: 2011;
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Keywords: Mallotus philippensis | Hepatoprotective effect | Antioxidants | Carbon tetrachloride

ABSTRACT
Liver Toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study MEMP leaves is used to screen the hepatoprotective activity. Hepatotoxicity was induced in experimental animals by administration of carbon tetra chloride (CCl4) (25ml/kg, i.p.). Silymarin (25 mg/kg, p.o.) was used as the standard. Functional parameters like onset of sleep and duration of sleep, Biochemical Parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (SALP), total bilirubin and direct bilirubin were measured. Cytotoxicity of CCl4 was estimated by quantitating the release of malondialdehyde (MDA). The activity of tissue antioxidant enzymes namely super oxide dismutase (SOD), catalase (CAT), and the level of total protein (TP) were also measured. Histopathological evaluation of liver sections was also done. CCl4 administration in rats elevated the levels of SGPT, SGOT, SALP and bilirubin. Administration of MEMP significantly (P
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