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The Effect of Maternal Selenium Supplementation on Pregnancy Outcome and the Level of Oxidative Stress in Neonates

Author(s): H Boskabadi | F Rezagholizade Omran | F Tara | MP Rayman | M Ghayour- Mobarhan | A Sahebkar | S Tavallaie | MT Shakeri | DH Alamdari | M Kiani | BS Razavi | M Oladi | G Ferns

Journal: Iranian Red Crescent Medical Journal
ISSN 1561-4395

Volume: 12;
Issue: 3;
Start page: 254;
Date: 2010;
Original page

Keywords: Selenium | Prooxidant-Antioxidant balance | Neonate | Complication | Pregnancy

Background: Pregnancy is regarded as a condition which is usually accompanied by oxidative stress. This studywas undertaken to investigate the effect of maternal selenium supplementation during gestation on the level ofoxidative stress in neonates and the pregnancy outcome.Methods: In this double-blind trial, 179 primigravid pregnant women in the first trimester of pregnancy wererandomly assigned to receive 100 μg of selenium (Se group) or a placebo (control group) per day until delivery.The level of oxidative stress and serum selenium concentration was determined in the maternal and umblicalcord sera of the subjects. Oxidative stress was measured by means of a novel assay of prooxidant-antioxidantbalance (PAB). The incidence of any pregnancy complications and outcomes was also evaluated in all neonates,being fully examined and followed up until 45 days.Results: Although maternal selenium concentration was significantly higher in the Se group (p

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