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Effect of Metformin on Diabetes Mellitus Prevention in Pregnant Women with Risk Factors

Author(s): Shirin Niroomanesh | Masoumeh Dadashaliha | Farahnaz Ahmadi | Fatemeh Rahimi Sherbaf | Forough Forghani

Journal: Journal of Family and Reproductive Health
ISSN 1735-8949

Volume: 4;
Issue: 4;
Start page: 165;
Date: 2010;
Original page

Keywords: Gestational diabetes mellitus | Metformin | Prevention

Objective: This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM. Materials and methods: Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to  Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI ≥ 30 kg/m2, with normal results in the glucose challenge test (GCT) or the glucose tolerance test (GTT). Subjects were randomly split to two groups; 63 women (group A) who received metformin (500 mg, twice a day) and 126 women (group B) did not use metformin. Incidence  of gestational diabetes was compared between two groups. Results: The incidence  of gestational diabetes was significantly different between two groups (%1.4 in group A, %15.4 in group B) (p

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