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Effect of Metformin on Serum Ferritin Level in Women with Polycystic Ovary Syndrome

Author(s): Saeed Behradmanesh | Gholam-Hossein Ranjbar Omrani | Frida Ghazanfarpour | Azar Baradaran

Journal: Iranian Red Crescent Medical Journal
ISSN 1561-4395

Volume: 13;
Issue: 7;
Start page: 487;
Date: 2011;
Original page

Keywords: Ferritin | Polycystic Ovary Syndrome | Metformin

Background: Polycystic ovary syndrome (PCOS) is one of the most common diseases among women associatedwith various inflammatory reactants such as C-reactive protein (CRP) and ferritin. This study aimed to investigatethe effect of metformin on probable reduction of serum ferritin in patients with PCOS.Methods: This study was conducted on 45 patients with PCOS who had not other systemic diseases and did nottake any medications. Weight, waist and hip circumstances (WHR), body mass index (BMI), metabolic indexes,CRP, ferritin and “Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) ˝ were measured before thestudy. Metformin (500 mg/tid) tablets were prescribed for three months and then same above parameters werere-measured.Results: Of 45 patients, 19 (42.2%) were overweight and 14 (31.1%) were obese. After drug therapy, there was asignificant reduction in waist circumstance and serum ferritin. This reduction was significant only in the lean andoverweight groups but not in the obese group. There was not significant association between serum ferritin andCRP, HOMA-IR, BMI and WHR. There was not significant correlation between CRP and HOMA-IR and also BMI.Conclusion: The effect of metformin on reduction of serum ferritin was not significant just in obese group andwas not associated with metabolic and anthropometric indexes.
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