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Effect Model Law: An Approach for the Implementation of Personalized Medicine

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Author(s): Jean-Pierre Boissel | Riad Kahoul | Draltan Marin | Fran├žois-Henri Boissel

Journal: Journal of Personalized Medicine
ISSN 2075-4426

Volume: 3;
Issue: 3;
Start page: 177;
Date: 2013;
Original page

Keywords: treatment decision-making | effect model | personalized medicine

ABSTRACT
The effect model law states that a natural relationship exists between the frequency (observation) or the probability (prediction) of a morbid event without any treatment and the frequency or probability of the same event with a treatment. This relationship is called the effect model. It applies to a single individual, individuals within a population, or groups. In the latter case, frequencies or probabilities are averages of the group. The relationship is specific to a therapy, a disease or an event, and a period of observation. If one single disease is expressed through several distinct events, a treatment will be characterized by as many effect models. Empirical evidence, simulations with models of diseases and therapies and virtual populations, as well as theoretical derivation support the existence of the law. The effect model could be estimated through statistical fitting or mathematical modelling. It enables the prediction of the (absolute) benefit of a treatment for a given patient. It thus constitutes the theoretical basis for the design of practical tools for personalized medicine.

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Tangokurs Rapperswil-Jona

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