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Effect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat

Author(s): Najmeh Katebi | Yasaman Razavi | Shabnam Zeighamy Alamdary | Shiva Irani | Fariba Khodagholi | Abbas Haghparast

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 17;
Issue: 1;
Start page: 39;
Date: 2013;
Original page

Keywords: Morphine | Apoptosis | Nucleus accumbens | Conditioned Place Preference | Western blot | Rat

Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the NAc in rat brain by assessing the changes in apoptotic factors. Methods: To investigate the effects of 3 different doses (0.5, 5 and 10 mg/kg) of morphine on induction of apoptotic factors in the NAc after its sub-chronic consumption, conditioned place preference paradigm was used in three groups of rats compared with the control group that received saline, and then the changes in apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio were assessed by western blot technique. Results: Our results showed that apoptotic factors increase in all three groups treated with morphine. In the nucleus accumbens, morphine induced significant increase (p
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