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Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats

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Author(s): Mohsen Marzban | Ali Shahbazi | Mahdi Tondar | Mansooreh Soleimani | Masoomeh Bakhshayesh | Arash Moshkforoush | Mehdi Sadati | Siamak Alizadeh Zendehrood | Mohammad Taghi Joghataei

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 2;
Issue: 3;
Start page: 21;
Date: 2011;
Original page

Keywords: Mozart Music | BDNF | Hippocampus | Rat

ABSTRACT
Introduction: It has shown that listening to Mozart music can potentiate spatial tasks in human; and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the hippocampus. Here we investigated the effect of postpartum exposure to The Mozart music on BDNF concentration in the hippocampus of rat.Methods: Thirty male one day old newborn Wistar rats divided randomly in two equal experimental and control groups. Experimental group exposed to slow rhythm Mozart music (Mozart Sonata for two pianos KV 448, 6 hour per day; sound pressure levels, between 80 and 100 dB) for 60 successive days. The control group was kept in separate room with housing conditions like experimental group except music exposure. After 60 days the rats were euthanized and hippocampuses extracted; then the content of BDNF protein was measured using ELISA sandwich method. Results: Data analysis revealed that rats exposed to Mozart Sonata music had significantly increased BDNF content in the hippocampus as compared to control rats (P±0.01). The concentrations of BDNF were 86.30±2.26 and 94.60 ±6.22 ng/g wet weight in control and music exposure groups respectively.Discussion: Exposure to the Mozart music early in life can increase the BDNF concentration in the hippocampus in rats.
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