Academic Journals Database
Disseminating quality controlled scientific knowledge

The effect of Nigella sativa on learning and memory in male diabetic rats

Author(s): Mohammad reza Jalali nodoushan | Mehrdad Roghani

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 1;
Issue: 1;
Start page: 32;
Date: 2009;
Original page

Keywords: Nigella sativum | Learning | Memory | Diabetes Mellitus

  Abstract   Introduction: Diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the beneficial antidiabetic potential of Nigella sativum (NS ), this research study was conducted to evaluate the effect of chronic consumption of NS on learning and memory in diabetic rats using passive avoidance and Y-maze tests. Methods: Male Wistar rats were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. NS treatment continued for 1 month. For induction of diabetes, streptozotocin was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of study using passive avoidance test. Meanwhile, alternation behavior percentage was determined using Y maze. Results: There was a significant increase (p
Save time & money - Smart Internet Solutions     

Tango Jona
Tangokurs Rapperswil-Jona